The information of our products contained in this section is partial and for orientation purposes only. A health care professional or certified physician must always be consulted for an appropriate diagnosis and use of these medications.
BRAND DRUG SUBSTANCE PRESENTATION
Dosing may range between 8 and 32 mg per day.
Dosing is the same as for adults, with a minimum of 0.15 to 0.20 mg/kg.
Gemcitabine recommended dose is 1000 mg/m2, administered as a 30-minute IV infusion.
Gemcitabine was not tested in children.
The dose and dosing schedule of Monofer must be individually set for each patient, based on the calculation of the total iron deficit. The optimal hemoglobin target vary in different patients groups. Monofer dose is expressed in mg of elemental iron. The total dose of iron is calculated by the Ganzoni formula where hemoglobin is abbreviated as Hb: Total iron dose (mg iron) = body weight (A) x (Hb target - actual Hb) (B) 2.4 x (C) + iron for iron deposits (D) (mg iron) (A) It is recommended to use the patient's ideal body weight or pre-pregnancy weight. (B) To convert Hb (mM) to Hb (g/dl), Hb (mM) should be multiplied by the factor 1.611145. (C) Factor 2.4 = 0.07 x 10.000 x 0.0034 %((%0.0034: the iron content of hemoglobin is 0.34% - 0.07: blood volume is 70 ml/kg body weight = 7% of body weight - 10.000: the conversion factor 1 g/dl = 10.000 mg / l%))%. (D) For a person weighing more than 35 kg body weight, iron stores are approximately 500 mg. The iron deficiency anemia will not appear until the total iron deposits have been depleted. Iron therapy should therefore replenish both hemoglobin iron and iron stores. After the total iron deficiency is corrected, patients may require continuous Monofer therapy to maintain the hemoglobin target levels and acceptable limits of other iron parameters.
Iron therapy in patients with bleeding must provide the iron amount equivalent to the amount of iron represented by the loss of iron. If Hb levels are reduced: Use the previous formula considering that the iron deposits need not be recovered: total iron dose (mg of iron) = (A) x (B) x (C). If the volume of bleeding is unknown, administration of 200 mg of Monofer results in increased hemoglobin is equivalent to 1 blood unit: Iron to be replaced (mg iron) = number of blood lost x 200 units.
Often, a few minutes after administration, anaphylactoid reactions occur due to parenteral iron, therefore, strict observation is necessary. If at any time during the intravenous administration of Monofer any signs of hypersensitivity reaction or intolerance are detected, administration must be stopped immediately. When a dose of parenteral iron is administered, must be available both medication for resuscitation and trained staff to evaluate anaphylactoid reactions. Children and adolescents: Monofer use in children and adolescents under 18 years is not recommended due to insufficient data on safety and efficacy. Adults and elderly: Monofer can be administered either as intravenous bolus injection as total dose infusion and intravenous drip or direct injection into the venous branch of the dialyzer. Monofer has not to be administered concomitantly with oral iron preparations since the absorption of oral iron can be decreased. Intravenous bolus injection: Monofer can be administered as intravenous bolus injection of 100-200 mg up to 3 times a week at a frequency of administration of 50 mg iron / minute. It can be diluted in 10 to 20 ml of 0.9% sodium chloride sterile solution. Total dose infusion: Monofer can be administered as infusion of total dose in which the total iron dose is administered in a single infusion. It is administered as a single dose of up to 20 mg iron/kg body weight as an intravenous drip infusion. Dose of 0-10 mg of iron/kg body weight may be infused for 30 minutes. Dose of 11 to 20 mg iron/kg body weight may be infused over 60 minutes. If the total dose of iron exceeds 20 mg iron/kg body weight, the dose may be divided in 2 administrations at an interval of at least one week. Monofer should be added to 100-500 ml of 0.9% sterile chloride solution. Total dose infusion has been associated with an increased incidence of adverse events, including delayed hypersensitivity reactions. Intravenous administration of Monofer by the method of infusion of total dose should be restricted to hospital use. Intravenous drip infusion: Monofer can be administered at doses of 200-1000 mg once a week until the total iron dose has been administered. Dose of 0-5 mg of iron/kg body weight must be infused for 15 minutes, 6-10 mg for 60 minutes and 11 to 20 mg for 60 minutes. Monofer should be added to 100-500 ml of 0.9% sterile sodium chloride. Injection into the dialyzer: Monofer can be administered during hemodialysis directly into the venous branch of the dialyzer under the same procedures defined for intravenous bolus injection.
Sale under filed prescription only
Each coated tablet contains Abiraterona Acetate 250 mg
Pharmacotherapeutic group: endocrine therapy, other hormone antagonists and related agents.
ATC code: L02BX03
Dosage and Administration
The recommended dose is 1,000 mg (four 250 mg tablets) as a single daily dose that must not be taken with food. Taking the tablets with food increases systemic exposure to abiraterone.
Abiraterone Acetate is to be taken with low dose prednisone or prednisolone. The recommended dose of prednisone or prednisolone is 10 mg daily.
Treatment with Abiraterone Acetate should not be reinitiated until symptoms of the toxicity have resolved to Grade 1 or baseline.
There is no relevant use of Abiraterone Acetate in the paediatric population.
Cardboard box containing 120 coated tablets.
1 mg/kg/day in 1 single dose or 0.8 mg/kg/day for 2 consecutive days, or 0.6 mg/kg/day during 3 consecutive days.
Note: Products which are still under patent are manufactured according to Argentinean requirements. Please note that they are delivered only to countries where the substance and its use are not protected by patents.